17. September 2018
The growing interest on polymeric delivery systems for pulmonary administration of drugs anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that uses the pulmonary route as the natural route of infection. Polymeric microparticles or nano-in-microparticles offer target delivery of drugs to the lungs and the potential to control and sustain drug release within TB infected macrophages improving the efficiency of the anti-TB treatment and reducing side effects....
28. November 2017
Recent work has established polymer strip films as a robust platform for delivery of poorly water-soluble drugs via slurry casting, in particular using stable drug nanosuspensions. Here, a simpler, robust method to directly incorporate dry micronized poorly water-soluble drug, fenofibrate (FNB), is introduced. As a major novelty, simultaneous surface modification using hydrophilic silica along with micronization was done using fluid energy mill (FEM) in order to reduce FNB hydrophobicity and...
01. October 2016
Abstract Flashing at tablet edges, an inevitable phenomenon when tableting a plastically deforming material under a high pressure, can introduce significant errors to tablet density and porosity determinations due to overestimated tablet thickness when tablet were measured out-of-die. Errors in tablet density determination also lead to errors in true density obtained by the Sun method, which is suitable for water-containing solids. Errors in true density and tablet porosity propagate to...
20. September 2016
Abstract Formation of core-shell nanocomposites of Fenofibrate and Itraconazole, model poorly water soluble drugs, via fluidized bed (FB) coating of their well-stabilized high drug loaded nanosuspensions is investigated. Specifically, the extent of dissolution enhancement, when fine carrier particles (sub–50 μm) as opposed to the traditional large carrier particles (>300 μm) are used, is examined. This allows testing the hypothesis that greatly increased carrier surface area and more...
24. August 2016
Abstract The present study summarizes the experimental characterization of a new continuous powder mixer (GCG-70 by Glatt®) using common pharmaceutical ingredients. The powder hold-up and residence time distribution were used to characterize the bulk behavior of the mixer as a function of impeller rotational speed, total throughput (mass flow rate) and blade configuration. The relative standard deviation (RSD), calculated from samples taken at the outlet of the blender, was used to...
08. December 2015
Highlights • Geldart group C ibuprofen particles were silica dry coated to enable fluidization. • Aeration testing and flow function coefficient were indicative of fluidizability. • Dry coated ibuprofen powders could be fluidized and polymer film coated. • Polymer suspensions with stabilized colloidal silica led to reduced agglomeration. • Scalable coating conditions were determined for the micronized ibuprofen powders. More
11. August 2015
The development of inhaled products to treat or to prevent lung infection is a very active research field in drug delivery. The pulmonary route is extremely attractive but very challenging. This paper reports the study of excipient, capsule brand and device influence on the aerodynamic behavior of dry powder formulations to treat tuberculosis. More