14. September 2017

The purpose of this study was to formulate compression coated tablets of mesalamine and prednisolone for colon specific delivery and evaluate their in vitro and in vivo performances.

03. August 2016

Abstract In this work, a platform of alginate beads loaded with Prednisolone in hypromellose/gellan gum capsules (F6/Cps) able to delay steroidal anti-inflammatory drug (SAID) release as needed for chronotherapy of rheumatoid arthritis is proposed. Rheumatoid arthritis, showing a worsening in symptoms in the morning upon waking, is a pathology that can benefit from chronotherapy. With the aim to maximize prednisolone therapeutic action allowing the right timing of glucocorticoid therapy,...

28. July 2016

Abstract Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insoluble ethylcellulose and various calcium salts, were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and...

12. April 2016

Highlights • We develop calcium pectinate gel beads using pectins from the cell walls of callus cultures. • The bead systems from callus culture pectins show a high stability at pH 1.25 and pH 7.0. • Controlled release appeared to be related to the higher linearity, Mw and the lower DE of the pectins. •Callus cultures pectic gels can be proposed as potential systems for colon-targeted drug delivery. More

09. December 2015

23. November 2015

22. September 2015

Inflammatory bowel disease (IBD) is one of the five most prevalent gastrointestinal disease burdens which commonly require lifetime care. Worldwide incidence rate of ulcerative colitis and Crohn's disease is about 16.8% and 13.4% respectively. Colitis is an inflammation of the colon. Colon targeted drug delivery will direct the drug to the colon. More

20. April 2015

Witold Brniak, Ewelina Maślak, Renata Jachowicz doi:10.1016/j.ejps.2015.04.006 Orodispersible tablets (ODTs) and orodispersible films (ODFs) are solid oral dosage forms disintegrating or dissolving rapidly when placed in the mouth. One of the main issues related to their preparation is an efficient taste masking of a bitter drug substance…. http://www.sciencedirect.com/science/article/pii/S0928098715001499