05. March 2018
This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two HPMC grades were evaluated as matrix former: standard Methocel CR and directly compressible Methocel DC2. The feeding behavior of each formulation component was investigated by deriving feed factor profiles.
29. January 2017
ABSTRACT The administration of active compounds by the oral mucosa is an efficient method for the delivery of drugs and nutrients. This work aimed to develop and characterize orally disintegrating films (ODFs) based on starch and gelatin as carriers of vitamin C. The ODFs were produced using a casting technique by varying the concentrations of starch and gelatin (0, 20, 40, 60, 80, and 100 g of starch/100 g of polymer) and were characterized in relation to contact angle, opacity, surface...
02. April 2016
Research exploring pharmaceutical applications of native sorghum and maize crops is needed to improve their economic competitiveness. This work assesses the physicochemical and compressional attributes of pregelatinized sorghum and maize starches originating from Sudan and determines whether these attributes are superior than existing starches in pursuit of achieving quality attributes of pharmaceutical dosage formulations. Key words: Compression properties Disintegration time Heckel plot...
17. February 2015
Sonia Lefnaoui, , Nadji Moulai-Mostefa Open Access funded by King Saud University - Saudi Pharmaceutical Journal doi:10.1016/j.jsps.2015.01.021 http://www.sciencedirect.com/science/article/pii/S1319016415000341 Full manuscript available for download - see comment on pdf.file