14. February 2017

Abstract Starch is a naturally occurring polymer that is present in many green plants. Its nontoxic and nonirritant properties, as well as low cost, ease of modification, and versatility in use have placed starch in a leading position among polymers used as a pharmaceutical excipient. In many conventional tablets and capsules, starch is used as a diluent, disintegrant, binder, and lubricant. Starch has vital intrinsic properties that have made its pharmaceutical applications possible. It has...

16. August 2016

Abstract HPMC is a popular matrix former to formulate tablets with extended drug release. Tablets with HPMC are preferentially produced by direct compression. However, granulation is often required prior to tableting to overcome poor flowability of the formulation. While continuous twin screw granulation has been extensively evaluated for granulation of immediate release formulations, twin screw granulation of controlled release formulations including the dissolution behavior of the...

06. April 2016

The aim of this study was to evaluate the potential of twin screw granulation for the continuous production of controlled release formulations with hydroxypropylmethylcellulose as hydrophilic matrix former. Metoprolol tartrate was included in the formulation as very water soluble model drug. A premix of metoprolol tartrate, hydroxypropylmethylcellulose and filler (ratio 20/20/60, w/w) was granulated with demineralized water via twin screw granulation. After oven drying and milling, tablets were...

10. February 2016

Mannitol is a frequently used diluent in the production of tablets due to its non-hygroscopic character and low drug interaction potential. Although the δ-polymorph of mannitol has superior tabletability in comparison to α- and β-mannitol, the latter are most commonly used because large-scale production of δ-mannitol is difficult. Therefore, a continuous method for production of δ-mannitol was developed in the current study. Spray drying an aqueous solution of mannitol and PVP in a ratio...

17. January 2016

This study aimed to design a fixed-dose combination dosage form which provides a sustained release profile for both the freely water-soluble metformin HCl and the poorly soluble gliclazide, two antidiabetic compounds used to treat diabetes mellitus. More

05. October 2015

Highlights •First formal environmental risk assessment for pharmaceutical excipients. •Based on material balances of single galenical productions at two sites. •PEC/PNEC risk ratios for wastewater treatment plants and the receiving water. •No risk identified for wastewater treatment or receiving water (River Rhine). More

21. September 2015

Hot Melt Extrusion (HME) is a well-known process within the plastic and food industries that has been utilized for the past several decades and is increasingly accepted by the pharmaceutical industry for continuous manufacturing. For tamper-resistant formulations of e.g.opioids, HME is the most efficient production technique. The focus of this study is thus to evaluate the manufacturability of the HME process for tamper-resistant formulations. More

26. May 2015

May 26, 2015 Largest investment in North America in the past five years Completion of the plant is scheduled for the end of 2017 Energy-saving tire trend drives demand for precipitated silica in North America Evonik Industries has started basic engineering for a new production plant for precipitated silica with focus on the rubber and especially the growing tire industry. The world-scale facility is planned to be built in the South East of the United States, in close proximity to major American...

17. March 2015

Nisso has completed production capacity expansion for NISSO HPC to respond to growth in worldwide demand. This supports growth of the the unique excipient NISSO HPC SSL-SFP, which can solve tablet manufacturing problems http://www.prweb.com/releases/2015/03/prweb12584601.htm