03. February 2016
Objective - Efficacy and safety of a novel multiple-unit hydromorphone once daily (HOD) was compared to an established hydromorphone twice daily (HTD) regimen in patients with moderate-to-severe chronic pain. Design and methods - The results from a randomized, double-blind, multicenter, cross-over trial in patients (n = 37) with chronic malignant or non-malignant pain are reported. Primary efficacy parameter was current pain on 0-100 mm VAS assessed 4-times daily and prior to intake of rescue...
28. October 2015
Polymethacrylate polymers are commonly used for the coating of prolonged-release pellets. Due to environmental and other concerns, aqueous latex dispersions are preferred over organic solutions. When using aqueous dispersions, a curing step is needed to ensure complete film formation. The aim of the present work was to investigate the impact of the curing process parameters on diclofenac sodium release from pellets coated with Eudragit RS and RL 30D. More