25. June 2018
The blending of powders is a critical step in pharmaceutical drug product manufacturing as it ensures that each dosage unit will contain the same intended fraction of active pharmaceutical ingredient (API). Under-blending thus poses a significant risk to patients where overdose or underdose can occur. Similarly, over-blending can lead to manufacturing issues such as reduced tablet tensile strengths as any included lubricants are dispersed further and further with additional blending. For these...
13. April 2017
Abstract Microwave resonance technology (MRT) is known as a process analytical technology (PAT) tool for moisture measurements in fluid-bed granulation. It offers a great potential for wet granulation processes even where the suitability of near-infrared (NIR) spectroscopy is limited, e.g. colored granules, large variations in bulk density. However, previous sensor systems operating around a single resonance frequency showed limitations above approx. 7.5% granule moisture. This paper describes...
12. June 2015
he principal component of many solid pharmaceutical formulations and indeed of dry powder inhalers, rather than being an active pharmaceutical ingredient (API), is most likely to be lactose. It is an excipient that fulfils a number of functions including those of diluent, flow-aid and API carrier. More Pulmonary Drug Delivery: Advances and Challenges Published Online: 29 MAY 2015 DOI: 10.1002/9781118799536.ch7