09. January 2017
Abstract The purpose of this study was to compare the chemical and physical stability of amorphous solid dispersions of Ritonavir formulated with either AFFINISOL™ HPMC HME 15LV or copovidone at 3 drug loads when placed on accelerated stability testing for a period of 6 months. Additionally, dissolution performance of the resulting amorphous solid dispersions before and after stability testing was analyzed to investigate the impact of storage and drug load on performance maintenance with each...
16. February 2016
Polyvinyl alcohol has received little attention as a matrix polymer in amorphous solid dispersions (ASDs) due to its thermal and rheological limitations in extrusion processing and limited organic solubility in spray drying applications. Additionally, in extrusion processing, the high temperatures required to process often exclude thermally labile APIs. The purpose of this study was to evaluate the feasibility of processing polyvinyl alcohol amorphous solid dispersions utilizing the model...
06. February 2016
The aim of this study was to develop a nanotechnology to formulate a fixed-dose combination of poorly water-soluble drugs in a children-friendly, flexible solid dosage form. For diseases like HIV, pediatric patients are taking multiple drugs for effective treatments. Fixed-dose combinations could reduce pill burdens and costs as well as improving patient adherence. However, development of fixed-dose combinations of poorly water-soluble drugs for pediatric formulations is very challenging. We...