19. June 2017

In this study, the origins of granule content non-uniformity in the high-shear wet granulation of a model two-component pharmaceutical blend were investigated. Using acetaminophen as the active pharmaceutical ingredient (API) and microcrystalline cellulose as the excipient, the distribution of the API across the granule size classes was measured for a range of conditions that differed in the duration of the initial dry mixing

05. February 2016

30. March 2015

Elsevier - Powder Technology - Available online 21 March 2015 This work focuses on the content non-homogeneity in granules across size classes in a high shear wet granulation process as a result of powder segregation during dry mixing coupled with preferential wettability of the one of the ingredients with the binder fluid... http://www.sciencedirect.com/science/article/pii/S0032591015002132