20. March 2017

Abstract In the early development stage of orally disintegrating films (ODFs), suitable evaluation methods must be used. The aim of this study was to demonstrate the feasibility of using an electronic taste sensor and a flow-through cell for ODFs. A pullulan film loaded with donepezil hydrochloride (DH) was designed, as a model ODF. The film was prepared using the solution/solvent casting method. First, the dissolution profiles were compared by using a paddle method (PD) and a flow-through cell...

11. October 2016

Abstract The overall performance of a potentiometric electronic tongue (ET) as well as the sensitivity and selectivity pattern of particular ion-selective electrodes forming the array towards exemplary APIs (metamizole sodium, pseudoephedrine sulphate) and excipients (hypromellose, carmellose, Eudragit E) was determined. Simultaneous sensing of both API and the encapsulating excipient in their physical mixture was noticed using potentiometric sensors. Usually, such altering of chemical image is...

13. April 2016

The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. Firstly, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets (ODTs), are tested using two different taste sensors. Secondly, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the...