04. October 2015
Polyvinyl acetate (PVAc) nanoparticles improved the tensile properties of maltodextrin films. Maltodextrin and PVAc are immiscible. Plasticizers favored the homogenous dispersion of PVAc to the concentration of 10% w/w.
04. October 2015
Calcium carbonate can be 'functionalized' by use of etching agents such as phosphoric acid to create inter- and intra-particle porosity with a range of morphologies. Functionalized calcium carbonate has potential for use as a carrier for the delayed release of actives, such as drugs, plant protection chemicals, and food additives such as flavors. The drug or flavor is released slowly by permeation and diffusion. More
30. September 2015
The finalists of the 2015 CPhI Pharma Awards have been revealed. Best Innovation in Manufacturing Technology, in partnership with Pharmaceutical Technology—Harro Hoefliger, Palladio, and Viavi Best Innovation in Process and Formulation Development—Supercritical Solutions, Codexis, and Catalent Best Innovation in APIs and Excipients—OMYA International AG, Aurena, and NOF Corporation Best Innovation in Supply Chain & Logistic Management—Aesica and Trace Link Best Innovation in...
30. September 2015
Three World-renowned experts – Bikash Chatterjee, President and CSO, Pharmatech Associates; Emil Ciurczak, President at Doramaxx; and Brian Carlin, Director Open Innovation at FMC – look at the implications of QbD, continuous processing, excipient criticality, and process validation on pharma manufacturing. The overall findings reveal there is clearly now a global commitment to move forward with the principles of QbD, however, the rate of adoption remains highly uneven. At the advanced end...
29. September 2015
The purpose of this study was to evaluate the performance of synthetic magnesium aluminometasilicate (MAS) as a novel inorganic carrier in hot melt extrusion (HME) processing of indomethacin (IND) for the development of solid dispersions. A continuous extrusion process at various IND/excipient blend ratios (20%, 30% and 40%) was performed using a twin - screw extruder. More
29. September 2015
Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers More
29. September 2015
Novel orally disintegrating system based on multiparticulate form was developed, offering an alternative to encounter major issues in the design of dosage form for pediatric patients, i.e. the difficulty in swallowing large solid dosage form (tablet or capsule), and the requirement to cover a broad range of doses for different age groups. Microcrystalline cellulose-based pellets containing acetaminophen were prepared via extrusion/spheronization followed by freeze-drying. More