30. September 2016

Abstract Combining two or more antiretroviral drugs in one medical product is an interesting but challenging strategy for developing topical anti-HIV microbicides. We developed a new vaginal delivery system comprising the incorporation of nanoparticles (NPs) into a polymeric film base – NPs-in-film – and tested its ability to deliver tenofovir (TFV) and efavirenz (EFV). EFV-loaded poly(lactic-co-glycolic acid) NPs were incorporated alongside free TFV into fast dissolving films during film...

30. September 2016

Sodium cromoglycate (SC) is an antiasthmatic and antiallergenic drug commonly used for chronic inhalation therapy; however, many daily intakes are required due to the fast drug clearance from airways. For these reasons, SC polymeric particles for inhalatory administration with adequate aerosolization and mucoadhesive properties were designed to prolong the drug residence time in the site of action. Sodium carboxymethylcellulose (CMCNa), sodium hyaluronate, and sodium alginate were selected to...

30. September 2016

Abstract The moisture content of granules in fluidised bed drying, granulation and coating processes can typically be between 1%~25%, resulting in the change of permittivity and conductivity during the processes. Electrical capacitance tomography (ECT) has been used for this purpose, but has a limit because too much water can cause a problem in capacitance measurement. Considering that microwave tomography (MWT) has a wide range of frequency (1~2.5 GHz) and can be used to measure materials with...

30. September 2016

Abstract: The choice of proper excipients is one of the key factors for successful formulation of pharmaceutical dosage forms. Increasing number of new therapeutic compounds suffers from poor solubility and/or bioavailability, creating a challenge from the drug formulation point of view. Problems have also been encountered in attempts to formulate biological drugs such as peptides and proteins, considering their sensitivity towards certain production processes and routes of administration. In...

30. September 2016

Abstract Despite the numerous advantages of powder formulations, few studies have described their nasal drug absorption. The first aim of this study was to compare the drug absorption from powder formulation with that from a liquid formulation in rats. Since pharmaceutical excipients are usually added to most powder formulations, the second aim of the study was to investigate the effect of hydroxypropyl cellulose (HPC) on nasal drug absorption from the powder. Three types of HPC with different...

29. September 2016

BASF announced on Sept. 27, 2016, the opening of a new plant for the manufacturing of polyvinylpyrrolidone (PVP) at the BASF site in Shanghai, China. The plant will produce PVP K30 powder, a polymer used as a base for several applications including pharma excipients. The site is equipped with production facilities, a quality control laboratory, and warehousing capacity. The facility operates in compliance with local and international Good Manufacturing Practice standards, including those...

29. September 2016

All excipients are indispensable in a formulation, but not all of them are crucial to the design or performance of the finished product. The current approach used by pharmaceutical manufacturers to classify process parameters and quality attributes as being critical or non-critical is too simplistic to adequately reflect current science- and risk-based approaches to product quality, noted Brian Carlin, director, Open Innovation at FMC, and a CPhI expert panel, in the 2016 CPhI Annual Industry...

28. September 2016

Abstract Wet granulation is the process of forming agglomerates from fine powder with the addition of granulating liquid and agitation, forming liquid bridges to hold powder particles together. In solid dosage form production, continuous wet granulation is used to reduce dust formation and improve flowability, compactability, and content uniformity of the intermediate product and facilitate downstream handling. Twin screw granulation (TSG) has gained increasing interest in the pharmaceutical...

28. September 2016

Abstract Lipid nanoparticles and their multiple designs have been considered appealing nanocarrier systems. Bringing the benefits of these nanosystems together with conventional coating technology clearly results in product differentiation.This work aimed at developing an innovative solid dosage form for oral administration based on tableting nanostructured lipid carriers (NLC), coated with conventional polymer agents. NLC dispersions co-encapsulating olanzapine and simvastatin (Combo-NLC) were...

26. September 2016

CPhI Worldwide, organized by UBM EMEA, has announced the findings of part i of the 2016 CPhI Annual Report on potential new approaches to improve quality and manufacturing process in pharmaceutical production ahead of CPhI Worldwide 2016 in Barcelona. Five World-renowned experts—Ajaz Hussain, Girish Malhotra, Brian Carlin, Pabir Basu & Thomas Friedli—propose improved methods to how industry evaluate and consider quality in the pharmaceutical industry, making a number of key...