09. April 2016
The aim of this study was to prepare and evaluate solid dispersion tablets containing a poorly water-soluble drug using porous calcium silicate (PCS) by a wet granulation method. Nifedipine (NIF) was used as the model poorly water-soluble drug. Solid dispersion tablets were prepared with the wet granulation method using ethanol and water by a high-speed mixer granulator. The binder and disintegrant were selected from 7 and 4 candidates, respectively. The dissolution test was conducted using the...
13. March 2016
Solid dispersion techniques are useful for improving the dissolution of poorly water-soluble drugs. This study aimed to produce and evaluate solid dispersion tablets improving the solubility and oral bioavailability of a poorly water-soluble indomethacin (IND) by wet granulation method with a high-speed mixer granulator combined with porous calcium silicate (PCS). A low density of PCS is a major disadvantage which is a bulky volume and scattering. So, it is necessary to prepare a high density...
29. October 2015
The aim of this study was to prepare and characterize chitosan-magnesium aluminum silicate (chitosan-MAS) microparticles, which can be used as matrix formers in sustained release tablets. The chitosan-MAS composites were prepared using spray drying. Physicochemical and micromeritic properties of the spray-dried chitosan-MAS microparticles were investigated. More