04. March 2016
Improving the solubility of BCS class 2 drugs is a continuing challenge for the pharmaceutical formulator. Improving solubility could allow for formulations using significantly less active and open the door to new dosage forms and avenues for lifecycle extensions. Creating solid dispersions are a promising way to improve drug solubility. Grace SilSol™6035 has a specifically engineered surface and pore distribution to enable stable amorphous dispersions by solvent deposition. Poorly soluble...
04. March 2016
The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid dispersions. Nifedipine (poorly water soluble drug), when prepared as solid dispersion showed increased solubility and dissolution rate. Solid dispersions of Nifedipine were prepared by using silsol 6035 as carrier in various proportions 10%, 20% and 30% by solvent loading (solvent droplet addition)method and various grades of silica by co-milling method in ratios of (1:1, 1:2 and 2:1). The...