14. December 2017
Purpose Artificial tears are widely used in the treatment of dry eye disease, although current formulations do not closely resemble natural tears. The purpose of this study was the design and characterization of a novel in situ gelling artificial tear formulation, containing both lipid and aqueous components, in order to resemble natural tears and replenish the tear film. Methods Liposomes, containing phosphatidylcholine, cholesterol, vitamins A and E, were prepared by the thin-film hydration...
31. March 2017
Abstract The aim of the present study was to establish a novel polymeric excipient for liquid nasal dosage forms exhibiting viscosity increasing properties, improved mucoadhesion and stability towards oxidation in solution.In order to achieve this goal, 2-mercaptonicotinic acid was first coupled to l-cysteine by disulfide exchange reaction and after purification directly attached to the polymeric backbone of xanthan gum by carbodiimide mediated amide bond formation. The resulting conjugate was...
24. March 2017
Abstract In situ gel drug delivery systems are in solution form before administration but once administered, undergo gelation in situ, to form a gel. In the present study nasal in situ gel of Phenylephrine hydrochloride was prepared for the treatment of nasal infections to provide sustained release of drug and to attain site specific action. Carbopol 934 was used as a pH triggered polymer and Poloxamer 188 was used as thermo sensitive agent. Different formulations were prepared by varying the...
22. March 2017
Abstract: Background: Conventional dosage forms of neomycin sulphate suffer from different drawbacks like spillage, poor penetration, low bioavailability, etc. In situ ophthalmic gel can overcome these problems by improving bioavailability, decreasing spillage and diminish the need for recurrent application. Thus, the aim of the present work was to prepare and evaluate in situ ophthalmic gel of neomycin sulphate for sustained ocular delivery. Method: Two polymers, sodium alginate (0.2-0.7%) and...
30. August 2016
Abstract In situ -gelling systems has the great potential in the wide areas of drug delivery. The application areas of such systems are broad and these systems can be formulated not only as gels but also as in situ gelling nanospheres, microspheres and liposomes. To overcome the drawbacks associated with conventional drug delivery systems and take advantages of both solutions and gels, such as accurate dosing, ease of administration of the former and longer precorneal residence of the latter, a...
23. June 2016
Abstract The objective of this study was to design a novel polyethylene glycol (PEG) derivative exhibiting mucus permeating and mucoadhesive properties. Therefore, the enzymatically degradable phosphate ester, phosphotyrosine (Ptyr) was covalently attached to PEG-diamine. The synthesized PEG-Ptyr was studied in terms of enzymatic degradability on Caco 2 cells and by isolated intestinal alkaline phosphatase (IAP). Furthermore, the influence of enzymatic degradation on charge distribution of the...
06. February 2016
The aim of this study was to develop a nanotechnology to formulate a fixed-dose combination of poorly water-soluble drugs in a children-friendly, flexible solid dosage form. For diseases like HIV, pediatric patients are taking multiple drugs for effective treatments. Fixed-dose combinations could reduce pill burdens and costs as well as improving patient adherence. However, development of fixed-dose combinations of poorly water-soluble drugs for pediatric formulations is very challenging. We...
24. December 2015
Pre-exposure prophylaxis (PrEP) is one of the best preventive strategies in protection against HIV/AIDS. The present research approach is development of novel topical thermosensitive mucoadhesive in situ gel for intravaginal use. Tenofovir disoproxil fumarate (TDF) has been loaded in the formulation and cold method was followed to prepare the various formulations. More