12. May 2018
The objective of this study was to evaluate non-crystalline cellulose (NCC) as a novel tablet excipient in solid oral dosage forms in comparison with microcrystalline cellulose (MCC) and silicified microcrystalline cellulose (Prosolv®, SMCC). Significance: MCC, although a widely used tablet excipient, has diasdvantages in terms of its low dilution potential for potent drugs, and sensitivity to lubricant and moisture. SMCC, a modified version of MCC, has improved tablet compression properties....
11. January 2018
Accelerating trends in the pharmaceutical industry have made successful technology transfer more critical than ever. Mergers, acquisitions, the rise of generics, the closing of plants and the construction of new ones -- these trends and events typically entail the transfer of products and processes from one site to another. New products, too, must often be moved from the development site to a manufacturing site prior to launch.
06. December 2017
The US FDA and EMA recently issued industry guidance focused on reducing risk associated with medication errors and
improving patient compliance. Recommendations are that varying color, shape, and size between dose strengths of a solid oral medication are useful tools to improve diff erentiation and minimize potential for errors. Additionally, visual differentiation of immediate and modifi ed release dosage forms of the same drug is essential to ensure overall patient safety.
09. August 2017
he use of unlicensed and off-label medicines in children is widespread and has raised an increasing concern over the last years. The majority of medicines taken by children are extemporaneously compounded by pharmacist, and there is a lack of information regarding bioavailability, suitability and stability. These formulations must be prepared from pure active substance and not from commercially available dosage forms. The development of paediatric formulations, particularly those suitable for ve