Combinatorial chemistry, computational molecular modeling and high throughput screening in drug discovery have significantly increased the number of poorly soluble drugs. About 40% of drugs developed in the past and about 90% of the drugs in development are poorly soluble drugs. When administered orally, a drug has to first dissolve in gastrointestinal fluids before it can be absorbed in to the blood and reach its site of action. The objective of this review article is to outline the key...
Drug solubility can pose a great challenge for the development of novel formulations and impacts a wide spectrum of drugs with poor solubilities. Drug efficacy is known to be proportionally related to the solubility of a drug. Poor solubility of a drug leads to low dissolution rate and in turn to low absorption in the gastrointestinal tract following oral administration. Pharmaceutical particle technology is often used to improve poor aqueous solubility of drug compounds that limits in vivo bioa
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The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology.