01. June 2017

Amorphous solid dispersions (ASD) are a common formulation approach for orally delivered small molecule active pharmaceutical ingredients (APIs) whose oral bioavailability (BA) is limited by dissolution rate and/or solubility in the gastrointestinal tract. Some of the foremost reasons this method has become so prevalent are the large potential for gains in bioavailability, easily assessable and mature manufacturing platforms, and straightforward integration of the resultant dispersions into an...

27. July 2016

The bioavailability of hydrophobic drugs strongly increases if they are formulated as amorphous materials because the solubility of the amorphous phase is much higher than that of the crystal. Moreover, the stability of these particles against crystallization during storage increases with decreasing particle size. Hence, it is advantageous to formulate poorly water-soluble drugs as amorphous nanoparticles. The formulation of an amorphous structure is often difficult, because many of these drugs...

22. July 2015

Several studies have shown the potential use of Ilex paraguariensis in developing products with the aim to protect biological systems against oxidative stress-mediated damages. In the same way, technological studies have demonstrated the feasibility of obtaining dry products, by spray-drying process, from aqueous extracts of I. paraguariensis in laboratory. More

03. March 2015

27. February 2015

February 2013, Vol. 39, No. 2 , Pages 402-412 (doi:10.3109/03639045.2012.685176) Marc Hugo, Klaus Kunath, and Jennifer Dressman http://informahealthcare.com/doi/abs/10.3109/03639045.2012.685176