31. August 2018
Combined micro- and nanosystems are appealing for pulmonary protein delivery, fulfilling the specific physiological requirements for efficient outcomes in-vivo. However, fabrication of protein formulations may impose stresses perturbing protein conformational stability and, hence, biological activity. Herein, a protein, insulin (INS), was nanoencapsulated inside chitosan nanoparticles (CS NPs) by ionic gelation. By spray drying, the resultant protein-loaded NPs were further encapsulated with a...
19. February 2018
The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and oleic acids at a suitable proportion were used to plasticize ethylcellulose. The effect of coating level, percentage of drug loading, inert core particle size, and composition of the coating formulation including the anti-sticking agent on the drug release profile were fully...
06. December 2017
Erythritol is a naturally abundant sweetener gaining more and more importance especially within the food industry. It is widely used as sweetener in calorie-reduced food, candies, or bakery products. In research focusing on sugar alternatives, erythritol is a key issue due to its, compared to other polyols, challenging production. It cannot be chemically synthesized in a commercially worthwhile way resulting in a switch to biotechnological production.
17. May 2017
•Sugars are soluble and sticky ingredients and their granulation may be difficult.
•Granulation performance of sugars in high shear granulation was evaluated.
•The use of a mixer torque rheometer was used to assess optimal amount of binder.
•The partial solubilization of the sugars increases the viscosity of the liquid bridges.
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Liquid amount required for the process is function of the sugar thickening power.
09. March 2017
ABSTRACT: The upcoming of biopharmacy in the 1950s resulted in various delayed, prolonged, sustained, extended, repeat action or in one word controlled release formulations. The establishment of those formulations is strongly connected to the development of multiparticulate drug delivery systems as they are especially suitable for achieving controlled release formulations with low risk of dose dumping while offering high flexibility in blending and outstanding reproducibility. The drug release...
12. March 2016
The mechanical strength, particle size and sphericity of starting sugar spheres for drug layering and subsequent functional coating applications are critical to achieving a reproducible and high yield final product. During early processing, spheres can be subjected to high mechanical stress that may result in the generation of fines, changes in particle size and loss of sphericity. The European Pharmacopoeia describes both a fluidization apparatus and an oscillating apparatus method for...
18. January 2016
HARLEYSVILLE, Pa.--(BUSINESS WIRE)--Colorcon, Inc. today announces the acquisition of the Pharmaceutical Sugar Spheres product line from Paulaur Corporation, a manufacturer of specialty sugar-based ingredients located in Cranbury, New Jersey. The addition of the Paulaur products complements Colorcon’s Suglets® Sugar Spheres product line and enhances Colorcon’s position as a leading global supplier of sugar spheres for the development of multiparticulate dosages. The agreement is specific...
15. July 2015
Poor water solubility of pharmaceutical candidates creates a big barrier to development and clinical applications. In this study, glipizide as a poorly water soluble drug was precipitated as nanoparticles and processed by spray drying to produce fast dissolving powders. Nanosuspensions of glipizide were prepared using the sonoprecipitation technique in the presence of selected stabilizers. Sorbitol, mannitol, and microcrystalline cellulose (Avicel) were involved in the formulations as the...
22. May 2015
Emilio Castelli established the Sugar Spheres production in 1968 to serve the pharmaceutical industry. http://ecastelli.com http://www.pharma-excipients.ch/excipientsource/excipient-supply/emilio-castelli/