06. February 2017

Abstract The aim of this study was to develop mucoadhesive pellets on a thiolated pectin base using the extrusion-spheronization technique. Thiolation of pectin was performed by esterification with thioglycolic acid. The molecular weight and thiol group content of the pectins were determined. Pellets containing pectin, microcrystalline cellulose and ketoprofen were prepared and their mucoadhesive properties were evaluated through a wash-off test using porcine intestinal mucosa. The in vitro...

26. February 2016

Extracted propolis has been used for a long time as a remedy. However, if the release rate of propolis isnot controlled, the efficacy is reduced. To overcome this issue, extracted propolis was added to a cryogen system. Propolis collected from southern Brazil was extracted using different methods and loaded at different concentrations into polyvinyl alcohol (PVA) and polyacrylic acid hydrogels as carrier systems. The material properties were investigated with a focus on the propolis release...

29. January 2016

The objective of the current research article is to provide a comprehensive review of excipients impact on the stability of the drug product and their implications during the product development. Recent developments in the understanding of the degradation pathways further impact methodologies used in the pharmaceutical industry for potential stability assessment. The formation of drug excipient adducts was very common based on the sensitive chemical moieties in the drugs and the excipients. The...

08. August 2015

The present study involved the use of old biomaterial starch as excipient for oral controlled drug delivery in which the properties of starch are tailored by chemical modification. Among the various commercially available starches, high amylose starch (HAS) was chosen and chemically modified ... More