18. July 2018
Tablets containing a theophylline–glutaric acid (TG) cocrystal dissociated rapidly forming crystalline theophylline (20–30%), following storage at 40 °C/75% RH for 2 weeks. Control tablets of TG cocrystal containing no excipients were stable under the same conditions. The dissociation reaction was water-mediated, and the theophylline concentration (the dissociation product), monitored by synchrotron X-ray diffractometry, was strongly influenced by the formulation composition. Investigation...
04. June 2018
The selection of the excipient(s) for a tablet formulation should take into account the API properties, process, target formulation and potential impact on the formulation. Some of those API properties can be Dose Particle Size Flow Properties Bulk Density Moisture Content Hygroscopicity Excipient Compatibility Compactability The following tables show some possible impacts on the tablet formulation and considerations to take into account. Pharmaexcipients.com thanks Fred Monsuur, Grace for the...