17. September 2018
The growing interest on polymeric delivery systems for pulmonary administration of drugs anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that uses the pulmonary route as the natural route of infection. Polymeric microparticles or nano-in-microparticles offer target delivery of drugs to the lungs and the potential to control and sustain drug release within TB infected macrophages improving the efficiency of the anti-TB treatment and reducing side effects....
02. February 2018
The human immunodeficiency virus (HIV) uses the brain as reservoir, which turns it as a promising target to fight this pathology. Nanoparticles (NPs) of poly(lactic-co-glycolic) acid (PLGA) are potential carriers of anti-HIV drugs to the brain, since most of these antiretrovirals, as efavirenz (EFV), cannot surpass the blood–brain barrier (BBB).
14. December 2017
Human population bears a similarity to an extent of 99.9%, however mere 0.1% of variability also creates large differences in personal make-up owing to several hereditary and environmental factors. Conventionally, development of healthcare modalities like diagnostics and therapeutics has been by mass production assuming uniformity in characteristics of recipient population. Due to the inherent variability in each individual clinical response to diagnostic and therapeutic products vary greatly...
03. April 2017
ABSTRACT The aim of the present work was to develop and evaluate sustained release colon targeted micropellets of lornoxicam in order to achieve release of the drug at colon which could result in enhanced local absorption and thereby improved bio-availability. The present worker prepared micropellets of lornoxicam in nine batches using pure drug, DCP, PVPK-30 and different ratios of HPMCK-4M taking into account the direct pelletization technique. Resulted micropellets were illed in capsules and...
02. April 2017
Abstract Artemisinin, a natural anti-malarial agent, also possesses anti-proliferative and anti-angiogenic activity in cancer cells with very low toxicity to normal healthy cells. Drug loaded magnetic nanoparticlesby using external magnetic field could selectively accumulate the drug at the target site and thereby reduce the doses required to achieve therapeutic concentration which may otherwise produce serious side effects on healthy cells. In the present study the artemisinin magnetic...
30. March 2017
Abstract Albeit the rapidly evolving knowledge about tumor biochemistry enables various new drug molecules to be designed as treatments, malignant central nervous system (CNS) tumors remain untreatable due to the failure to expose the entire tumor to such therapeutics at pharmacologically meaningful quantities. Therefore, drug delivery in CNS tumors must be properly addressed, as otherwise, novel therapies will continue to fail. In this regard, nanomedicine poses an appealing platform for...
08. March 2017
Abstract Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral bioavailability of tenofovir is relatively low, limiting its clinical effectiveness. Encapsulation of tenofovir within modified long-circulating liposomes would deliver this hydrophilic anti-HIV drug to the reticuloendothelial system for better therapeutic efficacy. The objectives of the current study were to prepare and pharmaceutically characterize...
18. September 2016
Inflammatory bowel disease (IBD) is an idiopathic, relapsing disease involving chronic inflammation of the digestive tract, either in part or entire. IBD primarily includes Crohn’s disease (CD) and ulcerative colitis (UC) with a high prevalence rate in the industrialized world, with North America noting the highest frequency of people suffering with CD [1]. Incidence of IBD is from 31 to 71 per100,000 people for CD and 18-31 per 100,000 for UC and is increasing at an alarming rate. Although,...
31. May 2016
Meloxicam (MLX) is a non-steroidal anti-inflammatory drug (NSAIDs) from the Oxicam family. This group of NSAIDs has been highly used in the treatment of rheumatoid arthritis and post-operative inflammation and is known as good antioxidants. Recently, their activity in chemoprevention, chemo-suppression, UV-sensitization and UV protection as also identified. MLX has been described as a COX-2 selective inhibitor. Its use has some advantages regarding to its selectivity, namely, less adverse...
03. May 2016
This research has investigated over different parameters and combined the additional anti-cancerous properties of high ester pectin based formulation, which exhibit almost negligible degradation by colonic bacteria. In present investigation compression coated tablets were prepared using high ester pectin derived from Mangifera indica fruit peel for colon specific delivery of 5-Fluorouracil. Pectin was extracted from dried fruit peel powder of Mangifera indica using water acidi ed with 0.2 M...