27. August 2018
Lipid excipients for oral drug delivery include high to low HLB solubility and bioavailability enhancers, lubricants, modified-release, taste-masking and API protection agents. Excipients are used in a variety of processes enabling the formulation of different dosage forms, mainly tablets and granules; hard and soft capsules. For information on excipient functionality and formulation with different processes please see the Formulation Technologies section.
20. June 2018
The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by...
26. April 2018
Are you a manufacturer of raw materials for the food, nutraceutical or pharmaceutical industry and interested to increase your product performance or functionality? Are topics like Dust free Solubility Protection Taste masking Targeted release Particle size Flowability relevant to you or for the life cycle management of your product? Then come to speak with the experts from IPC Process Center @Vitafoods Geneva Stand T167 - May 15-17, 2018. If not attending just drop us an email. Further...
17. April 2018
To circumvent the bad taste of drugs, many technologies are available, such as pro-drugs synthesis, formulating with flavors and sweeteners or coating drug particles with a lipid film. The versatility of the latter technology is particularly attractive and at Gattefossé we have worked on developing a simple, efficient and robust taste masking method. Simple We use a standard high shear mixer, very common equipment in the pharmaceutical industry, with a limited number of process parameters to...
06. April 2018
The development of effectively formulated oral drug products is key to ensuring patient compliance and desired clinical outcomes. Given the increasing regulatory expectations for the development of bespoke age-appropriate products, critical performance features now include palatability and overall acceptability in addition to standard drug-delivery requirements for oral medications. Understanding and modifying the taste attributes of aversive drug substances is, therefore, important. There are...
15. March 2018
presented by Glatt @ 11th Worldmeeting on on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology -19 March to 22 March 2018 Granada, Spain On the Glatt Booth N° 3 we will exhibit our smallest continuous granulation line and inform about our solutions in micropellets, taste masking, pediatric formulation, drug delivery, etc. From our Pharmaceutical Development origin the following poster contributions: Influence of polymer content on droplet size distributions in atomized spraying...
22. February 2018
Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate whether hot melt extrusion could be used to develop taste masked formulations of isoniazid and also to evaluate and correlate different taste assessment methods Two polymers with different physico-chemical properties, Soluplus and Eudragit E-PO were chosen as carriers for the drug. Eudragit E-PO has already been widely used for taste masking due to...
30. January 2018
Many drugs are bitter and overcoming this bitter taste is a major barrier in developing a successful product, especially for pediatric patients. Approaches to mask taste include changing taste perception, creating a physical barrier to separate the drug from interacting with taste buds, and changing drug solubility.
24. December 2017
Drug therapy for children is one of the cornerstone developments that have sharply reduced childhood mortality. Despite this, many challenges remain in ensuring that children receive safe and effective drug therapy. There are unique issues in treating children with oral medication relating to development, existing formulations and medication acceptability. Medication acceptability in children is complex relating to a wide range of factors, including drug palatability.
12. November 2017
Taste masking increases drug acceptability and medication adherence in pediatric, geriatric, and other special patient populations.