08. August 2018
Telmisartan (TS) have developed for the treatment of hypertension as the angiotensin II receptor blocker. TS belongs to class II drug in BCS classification and it has good permeability. But, it is poorly water soluble. Biological half-life of TS is 24 hours because it has not good bioavailability (only 42∼58%). The absorption of a drug is often limited by dissolution rate. Drug dissolution is important factor to the therapeutic efficacy of a medicine. Therefore, TS requires alternative...
26. March 2017
Aim: Telmisartan is an anti-hypertensive drug under the class of angiotensin II receptor blocker. The aim is to formulate and evaluated immediate release telmisartan tablets using hydrophilic polymers. Materials and Method: The hydrophilic polymers are polyethylene glycol 4000 (PEG-4000) and PEG-6000. Solid dispersion is prepared with polymers with different ratios 1:0.5, 1:1, 1:2 and formulated into tablets. Formulations were characterized for drug content studies, drug release studies, and...
05. February 2016
The aim of this study was to enhance the dissolution and bioavailability of telmisartan (TLM), a poorly water soluble drug by comilling approach. Physical mixtures of TLM and poly(vinyl alcohol) (PVA) were comilled in a planetary micro mill in a dry condition by varying process parameters such as drug to polymer weight ratio, ball-to-powder weight ratio, and rotational speed. The comilled products that offered cumulative percentage dissolution of TLM above 75% in 30 min (CG 1 and CG2). These...
16. July 2015
Highlights •The inclusion ratio was established by phase solubility study and Job Plot. •The complexes were characterized by DSC, XRPD, FTIR and SEM. •The complexes' configuration was proposed by Computer Molecular Modeling. •Complexes achieved dissolution rates comparable with the marketed reference medicine. •Complexes showed faster pharmacological effect than the free drug during in vivo studies More
14. July 2015
Telmisartan is poorly soluble in water, and the rate of dissolution, as well as bioavailability, is less. In the present study, an attempt has been made to improve the dissolution of the drug by coating the drug and carrier over sugar pellets. The solubility promoters such as alkalizes, binders and surfactants were selected to make the drug solution. The prepared pellets were evaluated for their physicochemical properties and in-vitro dissolution. The drug release rate was found to be more from...
27. April 2015
Eur J Pharm Sci. 2015 Apr 20. pii: S0928-0987(15)00155-4. doi: 10.1016/j.ejps.2015.04.012. Lipocalin-type prostaglandin D synthase (L-PGDS), a member of the lipocalin superfamily, possesses the function of forming complexes together with various small lipophilic molecules. In this study, we chose telmisartan as a model drug due to its pH dependent poor water solubility, and developed and characterized a novel solubilized formulation of telmisartan using a complex formulation with L-PGDS......