13. September 2018
This work demonstrates the feasibility of the extemporaneous preparation of maltodextrins orodispersible films (ODF) by hot-melt ram-extrusion 3D printing. This method consists of three simple technological operations which can be also implemented in a pharmacy setting. First, maltodextrins, drug, and other excipients are mixed in a mortar and wetted with the plasticizer (i.e. glycerine). Then, the mixture is fed in the chamber of the ram-extruder and heated. ODF are individually printed on the...
04. March 2017
Abstract Bacterial resistance to various antibiotics has been accelerated in recent years. Bacteriophages (phages) are natural particles that can attack bacteria. Phages can be used selectively for each particular strain. The best way for dealing with superficial infections is topical application of the drug. One of the best ways is the use of water-based gels, such as hydroxy propyl methyl cellulose (HPMC) based gels. In addition to sustained drug release properties of the gel base, HPMC...
06. February 2017
Abstract The oral route is an attractive delivery route for the administration of DNA-based therapeutics, specifically for applications in gene therapy and DNA vaccination. However, oral DNA delivery is complicated by the harsh and variable conditions encountered throughout gastrointestinal (GI) transit, leading to degradation of the delivery vector and DNA cargo, and subsequent inefficient delivery to target cells. In this work, we demonstrate the development and optimization of a hybrid-dual...
30. June 2015
The development and manufacture of novel nanocarriers for drug delivery has proved challenging with regards to scale-up and pharmaceutical quality. More