31. August 2018
Combined micro- and nanosystems are appealing for pulmonary protein delivery, fulfilling the specific physiological requirements for efficient outcomes in-vivo. However, fabrication of protein formulations may impose stresses perturbing protein conformational stability and, hence, biological activity. Herein, a protein, insulin (INS), was nanoencapsulated inside chitosan nanoparticles (CS NPs) by ionic gelation. By spray drying, the resultant protein-loaded NPs were further encapsulated with a...
29. August 2016
Introduction Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance where it has established its place in the broad spectrum of manufacturing operations and pharmaceutical formulation development. HME has been demonstrated as a robust, novel technique to make solid dispersions in order to provide 1.) time-controlled, 2.) modified, 3.) extended, or 4.) targeted drug delivery, resulting in improved bioavailability as well as taste masking...
23. September 2015
With the Glatt MODCOS (Modular Continuous System) process insert, batch versions of the GPCG 2 and GPCG 10 series can be easily converted to continuous fluid bed systems and integrated into a continuous process chain. More Information & Video