28. October 2017
The goal of study was to formulate and characterize pullulan based oral thin film (OTF) of zolmitriptan by solvent casting method. Based on preliminary trials, glass, PEG 400 and sucralose were selected as casting surface, water-miscible plasticizer and sweetener for OTF, respectively. A 32 factorial design was used to study the effect of amount of PEG 400 (X1) and sucralose (X2) as independent variables on tensile strength (Y1), elasticity (Y2), % in-vitro drug release in phosphate buffer of...
21. February 2017
Abstract The present investigation was undertaken with the objective of formulating Bufotenin for rapid dissolution of drug and absorption which may produce the rapid onset of action and also to improve the bioavailability of the drug. The fast dissolving strips were prepared by solvent casting method with the selection of HPMC E5, E15, K15, and Microcrystalline Cellulose (MCC), Polyvinyl Alcohol (PVA) as polymers and glycerol as plasticizer. Prepared lms were carried out for in vitro...
20. September 2016
Abstract Formation of core-shell nanocomposites of Fenofibrate and Itraconazole, model poorly water soluble drugs, via fluidized bed (FB) coating of their well-stabilized high drug loaded nanosuspensions is investigated. Specifically, the extent of dissolution enhancement, when fine carrier particles (sub–50 μm) as opposed to the traditional large carrier particles (>300 μm) are used, is examined. This allows testing the hypothesis that greatly increased carrier surface area and more...
25. July 2016
Present research was aimed with the objective of formulation of Zolpidem fast dissolving oral films, for rapid dissolution of drug and absorption, which may produce the rapid on set off action. The fast dissolving oral films were prepared by solvent casting method using various polymers like HPMC E5, HPMC E15, HPMC K15, microcrystalline cellulose and poly vinyl alcohol. Glycerol used as plasticizer. Prepared films were evaluated for various physicochemical parameters like film thickness,...
13. June 2016
Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, self-administrable, and fast dissolving dosage form; all of which makes it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual,...