15. December 2016

Abstract The aim of this study was the design and evaluation of an entirely S-protected thiomer as matrix for intraorally administered films. The highly bucco-adhesive gelatin thiomer was designed based on the ligand cysteamine which was connected via disulfide bond with the aromatic leaving group 2-mercaptopyrimidine-4,6-diol (2-MPD). The thiol ligand cysteamine 2-MPD (Cys-2-MPD) was synthesized via the coupling of dimerised 2-MPD to cysteamine (Cys) and then attached to gelatin scaffold via a...

09. June 2016

Aim The purpose of the present study was to generate a novel mucoadhesive thiolated pullulan with protected thiol moieties and to evaluate its suitability as mucosal drug delivery system. Methods Two different synthetic pathways: bromination-nucleophilic substitution and reductive amination including periodate cleavage were utilized to synthesize such thiolated pullulans. The thiomer (pullulan-cysteamine) with the highest amount of free thiol groups was further enrolled in a reaction with...

17. June 2015