20. December 2017
The formulation and manufacturing of parenteral biotherapeutic products occur at the interface of science and regulatory concerns.
28. January 2017
Abstract Increasing evidences have shown that many pharmaceutical excipients are not pharmacologically inert but instead have effects on several transport function of uptake and efflux drug transporters. Herein, we investigated whether the excipients frequently used in many drug formulations affect transport function of organic cation transporters (OCTs) that are responsible for elimination of cationic drugs. Our finding revealed that solubilizing agents, Tweens, showed the most significant...
15. December 2016
Abstract There is ample evidence that pharmaceutical excipients, which are supposed to be pharmacologically inactive, have an impact on drug metabolism and efflux transport. So far, little is known whether they also modulate uptake transporter proteins. We have recently shown that commonly used solubilizing agents exert significant effects on the function of organic anion uptake transporting polypeptides. Therefore, we investigated in this study the influence of frequently used pharmaceutical...
06. June 2016
Background: The drug-excipient compatibility studies were carried out with the possible excipients viz. Tween 80, Carbopol 940, chitosan, sodium alginate, and polycaprolactone (PCL) for their possible use in the formulation of eugenol loaded nanoemulsion gels and nanoparticles. Methods: The eugenol-excipient compatibility studies were carried out by visual observations, differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and high-performance thin-layer chromatography (HPTLC)....
30. November 2015
Itraconazole (ITZ) is a broad spectrum triazole antifungal drug and commercially available as oral forms. However, effective topical forms are interesting to avoid systemic adverse effects, to directly deliver antifungal drugs to the target sites and to enhance patient compliance [1]. Microemulsion-based hydrogel (MBH), semisolid form of microemulsion (ME), is one of novel formulations practically used as topical drug carriers [2]. This study aimed to develop formulations of ITZ-loaded MBHs...
24. November 2015
The drug-excipient compatibility studies were carried out with the possible excipients viz. Tween 80, Carbopol 940, chitosan, sodium alginate, and polycaprolactone (PCL) for their possible use in the formulation of eugenol loaded nanoemulsion gels and nanoparticles. More