20. February 2017

Abstract The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge gained through this study is intended to be used for a Quality by Design (QbD)-based formulation design approach and formulation optimization. A total of 9 preferred fillers and 9 preferred binders were selected for this study. The selected fillers and binders were extensively characterized...

08. July 2016

Abstract This paper highlights preliminary results related to a new dry granulation process that is run in a twin-screw extruder. This heat-activated dry granulation method can produce suitable dry granules representing an exciting new area for continuous granulation. However, the current method makes starting granulation difficult. It is believed that high compaction produces sufficient friction at the barrel wall to cause the binder to soften. Once a plug of dense granular matter is built up...

23. September 2015

With the Glatt MODCOS (Modular Continuous System) process insert, batch versions of the GPCG 2 and GPCG 10 series can be easily converted to continuous fluid bed systems and integrated into a continuous process chain. More Information & Video

08. September 2015

This study explored a high dose formulation with model drug aceta-minophen and investigated the formulation (different binder types) and process factors (temperature, screw speed, feed rate, binder solution addition etc.) impact in an extrusion granulator process. More