08. November 2016

Abstract The objective was to investigate poly vinyl acetate (Kollicoat® SR 30 D) and ammonio methacrylate copolymer (Eudragit® RL 30 D) blends as coatings to increase the mechanical robustness of hydroxypropyl methylcellulose (HPMC) matrix tablets. Poly vinyl acetate (Kollicoat® SR 30 D – KSR) was selected for its flexibility and ammonio methacrylate copolymer (Eudragit® RL 30 D – ERL) because of its high permeability. Films based on KSR:ERL blends were prepared by casting or spraying...

07. October 2016

In this study, nanostructured microparticles was developed with polycaprolactone (PCL), poly(vinyl alcohol) (PVAL) and nanoparticles of the commercial sodium clay NT-25® by using the spray drying technique. The systems obtained were characte- rized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The NMR 13C and FTIR...

14. March 2016

The aim of this study was to synthesize thiolated poly(vinyl alcohol) (PVA) and to evaluate its mucoadhesive properties. Thiourea and 3-mercaptopropionic acid were utilized in order to obtain thiolated PVAs, namely, TPVA1 and TPVA2, respectively. TPVA1 and TPVA2 displayed 130.44 ± 14.99 and 958.35 ± 155.27 μmol immobilized thiol groups per gram polymer, respectively, which were then evaluated regarding reactivity of thiol groups, swelling behavior and mucoadhesive properties. Both thiolated...

24. February 2016

Cinnarizine (CIN), a poorly soluble drug with erratic bioavailability due to pH dependent solubility has limited advantage to formulate oral solid dosage forms in subject having low gastric acidity. In present study precipitation-ultrasonication was used to fabricate nanosuspensions of cinnarizine stabilized by Poly vinyl alcohol (PVA) to enhance the bioavailability. We investigated the effects of PVA concentration (X1) and solvent to antisolvent ratio (X2) on the quality attributes like mean...

05. February 2016

The aim of this study was to enhance the dissolution and bioavailability of telmisartan (TLM), a poorly water soluble drug by comilling approach. Physical mixtures of TLM and poly(vinyl alcohol) (PVA) were comilled in a planetary micro mill in a dry condition by varying process parameters such as drug to polymer weight ratio, ball-to-powder weight ratio, and rotational speed. The comilled products that offered cumulative percentage dissolution of TLM above 75% in 30 min (CG 1 and CG2). These...

11. August 2015

Highlights • Surface modification of cellulose (MCC) with MCC-block-PIBVE. • MCC-block-PIBVE was produced by mechanochemical cationic polymerization. • Polymerization of IBVE was initiated by the isolated MCC mechano-cations. • Isolated MCC-mechano cations were produced by milling of MCC in vacuum. More

28. July 2015