Granulation is the process of joining multiple particles or grains together, typically using a binding agent although mechanical force has been used to bond the particle together as well. This brief will provide the reader with a basic understanding of the options available for wet granulation as well as the processing implications. Before moving on, the terminology of granulation versus agglomeration should be addressed. In a purely scientific sense these are synonymous but in the pharmaceutical industry, agglomeration is often used to describe over-granulation or forming granules too large or out of specification.
Wet Granulation Knowledge Brief
By Stephen Sirabian Glatt Air Techniques