27. March 2016

Nimesulide microspheres were prepared by the quasi-emulsion solvent diffusion method, using acetylated starches of the indigenous Ofada rice (Oryza glaberrima Steud) with degrees of substitution (DS) 1.42 and 2.62. A full 23 factorial experimental design was performed using DS (X1), drug:polymer ratio (X2) and polymer concentration (X3) as independent factors; size, entrapment, swelling and time taken for 80% drug release (t80) were the dependent variables. Contour plots were generated and data...

05. October 2015

22. July 2015

Highlights Nanoparticles of chitosan-sodium tripolyphosphate (CS-TPP) are formed in the dilute and semi dilute regime The degree of coil space-occupancy (product of concentration and intrinsic viscosity) is a fundamental parameter to consider in the preparation of CS-TPP nanoparticles In general, the size and zeta potential of the nanoparticles are determined by the the degree of acetylation (DA) of CS Two type of behaviors are recognized at low (DA<30%) or high (DA>%) The molar ratio of...