A rational approach towards the design of chitosan-based nanoparticles obtained by ionotropic gelation - Abstract

Highlights

  • Nanoparticles of chitosan-sodium tripolyphosphate (CS-TPP) are formed in the dilute and semi dilute regime
  • The degree of coil space-occupancy (product of concentration and intrinsic viscosity) is a fundamental parameter to consider in the preparation of CS-TPP nanoparticles
  • In general, the size and zeta potential of the nanoparticles are determined by the the degree of acetylation (DA) of CS
  • Two type of behaviors are recognized at low (DA<30%) or high (DA>%)
  • The molar ratio of glucosamine/TPP accounts for the DA of CS and also determine the physical properties of the nanoparticles

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