07. April 2017

Abstract High shear mixers are classically used for wet granulation because they provide granules with a high density and a high strength in a short granulation time. In this study, the high shear wet granulation process was employed using chlorpheniramine maleate as a model drug, since it represents an example of low dose drug employing 32 randomized full factorial design and optimized in terms of different properties using Response Surface Methodology (RSM) approach. The effect of binder...

24. March 2017

ABSTRACT Introduction: For almost two decades there has been intense debate about whether the amorphous solid state form could resolve the solubility problems and subsequent bioavailability issues of many small molecule drugs. Since the amorphous form is a high energy and unstable state of solid matter, any material in that form requires stabilization. Areas covered: This review examines the technologies being exploited to stabilize the amorphous state in co-amorphous formulations. The review...

06. March 2017

Abstract We applied the Quality by Design (QbD) approach to the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticle formulations encapsulating triamcinolone acetonide, and the critical process parameters (CPPs) were identified to clarify the correlations between critical quality attributes and CPPs. Quality risk management was performed by using an Ishikawa diagram and experiments with a fractional factorial design (ANOVA). The CPPs for particle size were PLGA concentration and...

10. January 2017

Abstract The purpose of this study was to determine the drug-polymer miscibility of GENE-A, a Genentech molecule, and Hydroxypropyl methylcellulose-acetate succinate (HPMC-AS), a polymer, using computational and experimental approaches. The Flory-Huggins interaction parameter,χ, was obtained by calculating the solubility parameters for GENE-A and HPMC-AS over the temperature range of 25–100 °C to obtain the free energy of mixing at different drug loadings (0-100%) using the Materials Studio...

06. January 2017

Abstract Microcrystalline cellulose (MCC) HiCelTM is native from cellulose, which is manufactured from wood pulp. Microcrystalline cellulose is made by hydrolysis reaction at temperature and pressure in presence of catalyst, which acts as reaction process increment. It is neutralized after completion of hydrolysis and intended to be used as to make microcrystalline cellulose powder. HiCelTM MCC is white crystalline, free flowing powder and medium in particles size. MCC is free flowing with...

20. June 2016

Highlights • Ophthalmic viscoelastic devices (OVDs) were designed composed of HPC and ɩ-carrageenan (Carr). • The rheological and compressional properties of the polymer blends were characterised. • HPC and Carr were shown to physically interact in both dilute and gel states. • Binary platforms offered a wide range of rheological and compressional properties. • Platforms containing 3% HPC and 1% or 2% Carr exhibited properties advantageous for use as OVDs Read more...

12. June 2016

Introduction: For almost two decades there has been intense debate about whether the amorphous solid state form could resolve the solubility problems and subsequent bioavailability issues of many small molecule drugs. Since the amorphous form is a high energy and unstable state of solid matter, any material in that form requires stabilization. Areas covered: This review examines the technologies being exploited to stabilize the amorphous state in co-amorphous formulations. The review emphasizes...

22. July 2015

Highlights Nanoparticles of chitosan-sodium tripolyphosphate (CS-TPP) are formed in the dilute and semi dilute regime The degree of coil space-occupancy (product of concentration and intrinsic viscosity) is a fundamental parameter to consider in the preparation of CS-TPP nanoparticles In general, the size and zeta potential of the nanoparticles are determined by the the degree of acetylation (DA) of CS Two type of behaviors are recognized at low (DA<30%) or high (DA>%) The molar ratio of...