15. March 2017
Abstract In this work, a bottom-up approach based on the study of polyelectrolyte interactions was performed in order to evaluate the effect of Prosopis alba exudate gum as novel excipient for fish oil encapsulation in composed calcium-alginate-chitosan beads. Emulsion and beads properties such as oil distribution, encapsulation efficiency, yield, microstructure and thermo-oxidative protection were evaluated. Alginate and gum exert a synergistic effect on emulsion stability properties, which...
20. July 2016
Abstract The purpose of this work was to develop a multiparticulate system exploiting the pH-sensitive prop- erty and biodegradability of calcium alginate beads for intestinal delivery of ceftriaxone sodium (CS). CS was entrapped in beads made of sodium alginate and sodium carboxymethylcellulose (CMC), acacia, HPMC K4M and HPMC K15M as drug release modifiers. Beads were pre- pared using calcium chloride as a cross-linking agent, followed by enteric coating with cellulose acetate phthalate...
25. May 2016
Abstract: The main aim of the present work was to develop colon specific piroxicam loaded alginate microspheres intended for the treatment of rheumatoid arthritis. A multiparticulate system with a combined property of pH sensitive and biodegradability was developed. Piroxicam microspheres were prepared by using ionotropic gelation technique and coated by using coacervation phase separation method using different ratios of eudragit S100 which is a pH sensitive polymer. Both coated and uncoated...
01. February 2016
We aimed to develop a suitable micropellet delivery system for Lansoprazole, a highly potent proton pump inhibitor and acid-unstable physiologically active anti-secretory compound. Although clinically manifested to be highly effective for treating acid reux-related diseases, poor water solubility and short gastric retention time, typically does not provide extended period of relief. Materials and method: Micropellets of the drug was prepared using ionotropic gelation technique, where gelation...
22. July 2015
Highlights Nanoparticles of chitosan-sodium tripolyphosphate (CS-TPP) are formed in the dilute and semi dilute regime The degree of coil space-occupancy (product of concentration and intrinsic viscosity) is a fundamental parameter to consider in the preparation of CS-TPP nanoparticles In general, the size and zeta potential of the nanoparticles are determined by the the degree of acetylation (DA) of CS Two type of behaviors are recognized at low (DA<30%) or high (DA>%) The molar ratio of...