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15. December 2016
Abstract Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1 ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three formulations consisted of a simple SOL/ITZ amorphous solid dispersion (ASD), an optimized...
05. June 2015
Highlights •Novel BC composites with improved mechanical integrity. •Sustained in vitro release of the antibiotic (levofloxacin) from the BC composites over an 8-week period. •Levofloxacin retained the antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis over an 8-week in vitro release period. •Biocompatible BC composites. See more