08. May 2016

Objective: To investigate the modulation of the wettability of excipients by types of surfactants and its impacts on the disintegration of tablets and drug release. Materials and methods: The critical micelle concentration (CMC) of surfactants including sodium dodecyl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS), dodecyl trimethyl ammonium bromide (DTAB), cetyltrimethyl ammonium bromide (CTAB) and polysorbate (Tween-20 and Tween-80) was obtained using the platinum ring method. Contact...

05. March 2016

Solubility parameters of HPMCAS have not yet been investigated intensively. On this account total and three dimensional solubility parameters of HPMCAS were determined by using different experimental as well as computational methods. In addition, solubility properties of HPMCAS in a huge number of solvents were tested and a Teas plot for HPMCAS was created. The total solubility parameter of about 24 MPa0.5 was confirmed by various procedures and compared with values of plasticizers. 20 common...

22. January 2016

Excipients used in the solid drug formulations differ in their NMR relaxation and 13C cross-polarization (CP) kinetics parameters.Therefore, experimental parameters like contact time of crosspolarizationand repetition time have a major impact on the registeredsolid state NMR spectra and in consequence on the results of the NMRanalysis. In this work the CP kinetics and relaxation of the most common pharmaceutical excipients: anhydrous α-lactose, α-lactose monohydrate, mannitol, sucrose,...