13C solid-state NMR analysis of the most common pharmaceutical excipients used in solid drug formulations Part II: CP kinetics and relaxation analysis

Excipients used in the solid drug formulations differ in their NMR relaxation and 13C cross-polarization (CP) kinetics parameters.Therefore, experimental parameters like contact time of crosspolarizationand repetition time have a major impact on the registeredsolid state NMR spectra and in consequence on the results of the NMRanalysis. In this work the CP kinetics and relaxation of the most common pharmaceutical excipients: anhydrous α-lactose, α-lactose monohydrate, mannitol, sucrose, sorbitol, sodium starch glycolate type A and B, starchof different origin, microcrystalline cellulose, hypromellose,ethylcellulose, methylcellulose, hydroxyethylcellulose, sodium alginate,magnesium stearate, sodium laurilsulfate and Kollidon® were analyzed.

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