22. January 2016

Excipients used in the solid drug formulations differ in their NMR relaxation and 13C cross-polarization (CP) kinetics parameters.Therefore, experimental parameters like contact time of crosspolarizationand repetition time have a major impact on the registeredsolid state NMR spectra and in consequence on the results of the NMRanalysis. In this work the CP kinetics and relaxation of the most common pharmaceutical excipients: anhydrous α-lactose, α-lactose monohydrate, mannitol, sucrose,...