31. August 2018
The main objective of the presented research was to prepare an innovative carrier as a filler for detection tubes in the form of double-coated pellets with a very significant color transition during the detection of cholinesterase inhibitors such as nerve agents, organophosphorus or carbamate insecticides in liquids that is observable visually and also spectrophotometrically at 412 nm. The pellet cores were prepared by the extrusion/spheronization method. Consecutively, two different coats...
04. July 2016
Abstract The technique of attaching the polymer polyethylene glycol (PEG), or PEGylation, has brought more than ten protein drugs into market. The surface conjugation of PEG on proteins prolongs their blood circulation time and reduces immunogenicity by increasing their hydrodynamic size and masking surface epitopes. Despite this success, an emerging body of literature highlights the presence of antibodies produced by the immune system that specifically recognize and bind to PEG (anti-PEG Abs),...
05. October 2015
In the production process of a pharmaceutical dosage form there are many sources of foreign particles to be included in the product starting at the production of API and excipients right up to the preparation and production on the final drug product. Contamination sources can be many including human interaction, equipment, process, etc. The current way to detect such particles is by visual inspection by human with several drawbacks such as: Light Repetitive accuracy Accuracy of Detection...