23. May 2015

Highlights • Thiolated gum karaya was found to contain 5.026 mM of thiol groups/gm of polymer. • Thiolation led to conjugates with improved properties than unmodified one. • Swelling and mucoadhesion was increased with increase in pH from 1.2 to 6.8. • TK tablets sustained the release of drug with no disintegration throughout study. • Thiolation did not affect biocompatibility of the polymer. http://www.sciencedirect.com/science/article/pii/S0144861715003902