Synthesis, characterization of thiolated karaya gum and evaluation of effect of pH on its mucoadhesive and sustained release properties

Highlights

• Thiolated gum karaya was found to contain 5.026 mM of thiol groups/gm of polymer.

• Thiolation led to conjugates with improved properties than unmodified one.

• Swelling and mucoadhesion was increased with increase in pH from 1.2 to 6.8.

• TK tablets sustained the release of drug with no disintegration throughout study.

• Thiolation did not affect biocompatibility of the polymer.

http://www.sciencedirect.com/science/article/pii/S0144861715003902