26. January 2017

Abstract Thiolated polymers are a promising new group of excipients, but their stability against atmospheric oxidation has not been investigated in detail, and only a few efforts have been made to improve their stability. The oxidation of the thiol groups in solutions of thiolated polymers may result in a decrease of mucoadhesion and unpredictable in situ gelation. The aims of our work were to study the stability of aqueous solutions of thiolated polymers and the effects of stabilizing...

01. April 2016

Acyclovir a BCS class III drug exhibits poor bioavailability due to limited permeability. The intention of this research work was to formulate and characterize thiolated xyloglucan polysaccharide nanoparticles (TH-NPs) of acyclovir with the purpose of increasing its oral bioavailability. Acyclovir-loaded TH-NPs were prepared using a cross-linking agent. Interactions of formulation excipients were reconnoitered using Fourier transform infrared spectroscopy (FT-IR). The formulated nanoparticles...

14. March 2016

The aim of this study was to synthesize thiolated poly(vinyl alcohol) (PVA) and to evaluate its mucoadhesive properties. Thiourea and 3-mercaptopropionic acid were utilized in order to obtain thiolated PVAs, namely, TPVA1 and TPVA2, respectively. TPVA1 and TPVA2 displayed 130.44 ± 14.99 and 958.35 ± 155.27 μmol immobilized thiol groups per gram polymer, respectively, which were then evaluated regarding reactivity of thiol groups, swelling behavior and mucoadhesive properties. Both thiolated...

22. December 2015

To design a novel preactived carboxymethyl cellulose derivative. Methods: First, carboxymethyl cellulose (CMC) was chemically modified by amide bond formation between primary amino group of cysteine (CYS) and carboxylic moiety of CMC mediated by carbodiimide. Second, obtained CMCCYS was preactivated with 2,2′-dithiodinicotinic acid. Designed CMC-S-S-MNA was characterized by FT-IR. Furthermore, cytotoxicity was conducted on Caco-2 cell line. Swelling behavior, erosion and release of novel...

06. July 2015

Highlights •Synthesis and characterization of cysteamine conjugated β-cyclodextrin (β-CD-Cys). •Conjugates showed no toxic effects on Caco-2 cells at concentrations of 0.5% (m/v). •Maximum 34.51-fold improved mucoadhesion on the porcine buccal mucosa. •Inclusion complexes resulted in 150-fold increased water solubility of miconazole nitrate. More

23. May 2015

Highlights • Thiolated gum karaya was found to contain 5.026 mM of thiol groups/gm of polymer. • Thiolation led to conjugates with improved properties than unmodified one. • Swelling and mucoadhesion was increased with increase in pH from 1.2 to 6.8. • TK tablets sustained the release of drug with no disintegration throughout study. • Thiolation did not affect biocompatibility of the polymer. http://www.sciencedirect.com/science/article/pii/S0144861715003902