12. February 2017

Abstract In this study, hypromellose acetate succinate (HPMCAS) stable submicronic particles loaded with a soy isoflavones extract, have been obtained by nano spray drying technology. HPMCAS has been used as excipient able to increase both stability and supersaturation levels of the active ingredients hence able to enhance skin penetration performance of genistein and daidzein. The influence of polymer/extract ratio as other process variables, on particle size, morphology and permeation...

24. October 2016

Purpose Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which is rapidly absorbed after oral administration exaggerating its side effects. The current work aims to prepare controllable release DSV matrix to reduce DSV side effects related to its initial burst. Methods Fifteen DSV matrix formulations were prepared using different polymers, polymer/drug ratios and matrix excipients and characterized using Differential Scanning Calorimetry (DSC), infra-red (IR)...

12. June 2016

Introduction: Amorphous solid dispersions are considered as one of the most powerful strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical ingredient (API) dispersed at the molecular level in an amorphous polymeric carrier. As the latter component constitutes the largest part of the formulation, its characteristics will contribute to a large extent to the properties and behavior of the solid dispersion. Areas covered: Amorphous polymers are most often used...

24. May 2016

The present investigation is an attempt to design and evaluate rapidly dissolving oral strips of metoprolol succinate, an anti-hypertensive agent. Rapidly dissolving oral strips were prepared by solvent casting technique using hydroxyl propylmethylcellulose-5 cps and polyvinyl alcohol as the lm forming polymers. The prepared strips were evaluated for the characteristics such as thickness, folding endurance, percent elongation, tensile strength, surface pH, percent drug content, in-vitro...

18. April 2016

The purpose of this study was to evaluate efficiency of fenugreek gum for developing gastro retentive floating tablets of Sumatriptan succinate when used alone or in combination with established polymers. The floating Tablet were prepared by direct compression and wet granulation technique and evaluated for various parameters like physical characterization, hardness, friability, weight variation, drug content uniformity, swelling index and in-vitro buoyancy and drug release. Fenugreek gum was...

09. April 2016

Sumatriptan succinate (SS) is a selective serotonin receptor agonist used for the treatment of migraine attacks, suffering from extensive first-pass metabolism and low oral bioavailability (∼14%). The aim of this work is to compare the performance of different ready-made co-processed platforms (Pharmaburst®, Prosolv ODT®, Starlac®, Pearlitol Flash®, or Ludiflash®) in the formulation of SS sublingual orodispersible tablets (ODTs) using direct compression technique. The prepared SS ODT...

10. November 2015

Tablets containing metoprolol succinate and Compritol®888ATO in the ratio of 1:2 yielded the desired sustained release profile in phosphate buffer pH 6.8 when evaluated using USP type II paddle apparatus and was selected as the optimized formulation. Robustness of optimized formulation was assessed by studying the effect of factors like varying source of metoprolol succinate and Compritol®888ATO, compression force and hydroalcoholic dissolution medium on the release profile. No significant...

23. May 2015

Highlights • Thiolated gum karaya was found to contain 5.026 mM of thiol groups/gm of polymer. • Thiolation led to conjugates with improved properties than unmodified one. • Swelling and mucoadhesion was increased with increase in pH from 1.2 to 6.8. • TK tablets sustained the release of drug with no disintegration throughout study. • Thiolation did not affect biocompatibility of the polymer. http://www.sciencedirect.com/science/article/pii/S0144861715003902