17. August 2017
For the development of this directly compressible excipient no chemical modification was applied. The enhanced functionality enabling a nearly zero order release was achieved by techniques such as physical mixing, high shear mixer granulation and spray drying.
08. November 2016
Abstract In the current study, we investigated the metoprolol absorption kinetics of an in-house produced oral sustained-release formulation, matrices manufactured via prilling, and two commercially available formulations, ZOK-ZID® (reservoir) and Slow-Lopresor® (matrix) in both New Zealand White rabbits and Beagle dogs, using a population pharmacokinetic analysis approach. The aim of this study was to compare the in vivo pharmacokinetic (PK) profiles of different formulations based on...
24. May 2016
The present investigation is an attempt to design and evaluate rapidly dissolving oral strips of metoprolol succinate, an anti-hypertensive agent. Rapidly dissolving oral strips were prepared by solvent casting technique using hydroxyl propylmethylcellulose-5 cps and polyvinyl alcohol as the lm forming polymers. The prepared strips were evaluated for the characteristics such as thickness, folding endurance, percent elongation, tensile strength, surface pH, percent drug content, in-vitro...
18. March 2016
The aim of this study was to develop, evaluate and compare extended release mini-matrices based on metoprolol tartrate (MPT) and either glyceryl behenate (GB) or glyceryl palmitostearate (GPS). Mini-matrices were produced by three different techniques: hot melt extrusion, compression of melt granulates and prilling. Hot-melt extrusion and compression of granules obtained from melted material proved to be reliable, robust and reproducible techniques with aim of obtaining extended release...
13. January 2016
Ethylcellulose is one of the most commonly used polymers to develop reservoir type extended release multiparticulate dosage forms. For multiparticulate extended release dosage forms, the drug release is typically governed by the properties of the barrier membrane coating. The ICH Pharmaceutical Development Guideline (ICH Q8) requires an understanding of the influence of critical material attributes and critical process parameters on the drug release of a pharmaceutical product. More
10. November 2015
Tablets containing metoprolol succinate and Compritol®888ATO in the ratio of 1:2 yielded the desired sustained release profile in phosphate buffer pH 6.8 when evaluated using USP type II paddle apparatus and was selected as the optimized formulation. Robustness of optimized formulation was assessed by studying the effect of factors like varying source of metoprolol succinate and Compritol®888ATO, compression force and hydroalcoholic dissolution medium on the release profile. No significant...
06. October 2015
The aim of the present study was to evaluate the solid state characteristics, drug release and stability of fatty acid-based formulations after processing via prilling and solid lipid extrusion. Myristic acid (MA), stearic acid (SA) and behenic acid (BA) were used as matrix formers combined with metoprolol tartrate (MPT) as model drug. More
19. September 2015
A clinical studywas conducted to validate the in vivo drug release performance of IntelliCap® CR capsules.12 healthy, male volunteers were administered IntelliCap® CR capsules, filled with metoprolol as a BCS 1 model drug, and programmed to release the drug with 3 different release profiles (2 linear profiles extending over 6 h and 14 h, respectively, and a pulsed profile with two equal pulses separated by 5 h) using a cross-over design. More
23. May 2015
Highlights • Thiolated gum karaya was found to contain 5.026 mM of thiol groups/gm of polymer. • Thiolation led to conjugates with improved properties than unmodified one. • Swelling and mucoadhesion was increased with increase in pH from 1.2 to 6.8. • TK tablets sustained the release of drug with no disintegration throughout study. • Thiolation did not affect biocompatibility of the polymer. http://www.sciencedirect.com/science/article/pii/S0144861715003902
20. May 2015
A novel self-developed technique ultra-fine particle process system (UPPS) which is quite different from existing technology was employed to prepare microspheres for oral administration. The obtained MT microspheres by UPPS were spheroidal solid particles in size of about 80-120 μm with good flowability, which were fit for tableting or capsulation. The in vitro release behavior of the MT microspheres was similar with commercial sustained release tablet of metroprolol succinate, Betaloc®, and...