06. February 2018
Melanoma is the most aggressive and lethal type of skin cancer, with a poor prognosis because of the potential for metastatic spread. The aim was to develop innovative powder formulations for the treatment of metastatic melanoma based on micro- and nanocarriers containing 5-fluorouracil (5FU) for pulmonary administration, aiming at local and systemic action.
18. January 2018
This work addresses the establishment and characterization of gellan gum:pectin (GG:P) biodegradable mucoadhesive beads intended for the colon-targeted delivery of resveratrol (RES). The impact of the polymer carrier system on the cytotoxicity and permeability of RES was evaluated. Beads of circular shape (circularity index of 0.81) with an average diameter of 914 μm, Span index of 0.29, and RES entrapment efficiency of 76% were developed.
16. November 2015
See also: First in-vivo biocompatibility study of Upsalite® is published!
31. May 2015
Dissolution of poorly water-soluble drug, Artemisinin (ART), was enhanced by encapsulating the drug particles inside pore channels of ordered mesoporous silica, SBA-15, via co-spray drying. Read More: http://informahealthcare.com/doi/abs/10.3109/02652048.2015.1035684
23. May 2015
Highlights • Thiolated gum karaya was found to contain 5.026 mM of thiol groups/gm of polymer. • Thiolation led to conjugates with improved properties than unmodified one. • Swelling and mucoadhesion was increased with increase in pH from 1.2 to 6.8. • TK tablets sustained the release of drug with no disintegration throughout study. • Thiolation did not affect biocompatibility of the polymer. http://www.sciencedirect.com/science/article/pii/S0144861715003902