05. December 2017

The work is based on pulsatile principles to deliver a programmed dose of Irbesartan, an angiotensin-II receptor antagonist for chronotherapy of hypertension induced by excessive secretion of aldosterone, thereby lower the blood pressure at early morning. Solid dispersion of Irbesartan, a BCS class II drug, was prepared by using Poloxamer-188 by melt method in ratio of 1:1 to increase the dissolution properties of drug.

11. October 2017

The objective of this study was to formulate, optimize and evaluate sustained release pellets of venlafaxine hydrochloride. Venlafaxine hydrochloride sustained release pellets were prepared by solution layering technique.