28. December 2016

Introduction: Diabetes mellitus (DM) is a worldwide disease with high mortality rate. Metformin hydrochloride has been used as the first-line drug for the treatment of DM Type 2. However, the high water solubility and short half-life lessen the potential effectiveness of using conventional metformin tablet. Floating tablet is an attractive pharmaceutical formula which can make the drugs staying with an adequate time in the absorption part of the gastrointestinal tract (i.e., the stomach), and...

28. July 2016

ABSTRACT Background: Gastroretentive floating microsphere containing Lafutidine, a second generation histamine H2–receptor antagonist were prepared by ionotropic gelation technique by using sodium alginate, HPMC K4M, ethyl cellulose as polymers, sodium bicarbonate as gas generating agent and calcium chloride as cross linking agent. Objective: To formulate a system to remain in the stomach for prolonged and predictable period in order to enhance the drug bioavailability. Method: They were...

20. July 2016

Abstract Objective: A novel multiparticulate system for the gastric delivery of Diltiazem (DTZ) was developed for effective treatment of hypertension. Materials and methods: Floating microspheres of ethylcellulose and Eudragit loaded with DTZ were successfully developed and evaluated for their gastro-retentive and controlled-release properties. The effect of various process variables on the particle morphology, micromeritic properties, in vitro floating behavior, percentage drug entrapment, and...

06. May 2016

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems,...

21. April 2016

The present study aimed to develop and optimize the wax based floating sustained-release dispersion pellets for a weakly acidic hydrophilic drug protocatechuic acid to achieve prolonged gastric residence time and improved bioavailability. This low-density drug delivery system consisted of octadecanol/microcrystalline cellulose mixture matrix pellet cores prepared by extrusion-spheronization technique, coated with drug/ethyl cellulose 100cp solid dispersion using single-step fluid-bed coating...

18. April 2016

The purpose of this study was to evaluate efficiency of fenugreek gum for developing gastro retentive floating tablets of Sumatriptan succinate when used alone or in combination with established polymers. The floating Tablet were prepared by direct compression and wet granulation technique and evaluated for various parameters like physical characterization, hardness, friability, weight variation, drug content uniformity, swelling index and in-vitro buoyancy and drug release. Fenugreek gum was...

08. April 2016

Aim: The main objective of the present research work was to develop floating microspheres of cefditoren pivoxel (CP) to provide the delivery of the drug at a sustained rate. Materials and Methods: Floating microspheres of CP were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC) K4M and ethyl cellulose as the rate controlling polymers. The optimization of formulation was carried out by 32 factorial design using two factors; a total amount of polymer (X1) and...

15. March 2016

Abstract: The purpose of the present study was to prepare floating matrix tablets of clarithromycin employing simplex lattice design. Hydroxypropyl methylcellulose (HPMC) and Ethyl Cellulose (EC) were used as matrix forming agents; sodium bicarbonate and citric acid as effervescence producing agents. Simplex lattice design was used as optimization technique employing three independent formulation variables viz. concentration of HPMC (X1), Citric Acid (X2), EC (X3) whereas floating lag time,...

08. March 2016

Introduction: Oral sustained release gastro retentive dosage forms offer several advantages for drugs having absorption from the upper gastrointestinal tract to improve the bioavailability of medications which have narrow absorption window. The aim of the study was to develop a floating bioadhesive drug delivery system exhibiting a unique combination of floatation and bioadhesion to prolong the residence in the stomach using atenolol as a model drug. Methods: Prior to compression, polymeric...