29. August 2018
Conversion of liquid and semisolid lipids into free flowing powders is an advantageous technique, as the carriers display high surface area, strong adsorption capacity, ease of processing, and ability to generate lipid loaded free flowing powders which can be converted to solid dosage forms like tablets and capsules. A combination of density, adsorption capacity and desorption is found to be of importance in the selection of the right adsorbent. Adsorbents like magnesium aluminium silicates...
22. December 2017
Grace’s SILSOL® technology offers solutions for poorly soluble active ingredients. Based on compendial silica and fully scalable, it gives pharmaceutical developers new options to enhance bioavailability of BCS2 compounds, especially during early research and discovery.
18. October 2017
WR Grace & Co has licensed rights to a bioavailability enhancement technology from Formac Pharmaceuticals NV.
24. February 2017
Lipid-based formulations (LBFs) can be effective drug delivery systems for poorly watersoluble chemical entities, provided they are designed with careful selection of the excipients, based on their role in the delivery system and in relation to the API properties. The primary factor leading to increased bioavailability by LBFs is the administration of the drug in a pre-dissolved state thus avoiding the dissolution limiting step. The fate of a drug formulated in a LBF is dependent on the ability...
21. July 2016
Applications of SYLOID® FP silica in Oral Dry Suspension of Antibiotics Unique silica helps to protect antibiotic formulations from moisture Helps enhances the storage stability and shelf life of finished dosage forms Helps improves the flow and liquid dispersion properties of powder formulations Βeta-lactam antibiotics such as Amoxicillin, cefuroxime, and Cefixime are often formulated with Potassium Clavulanate to avoid degradation from β-lactamase enzymes. Potassium Clavulanate is highly...
16. March 2016
Simethicone is viscous, greyish-white, opalescent preparation used as anti foaming agent to prevent formation of gas in gastro intestinal tract. As per USP, it is a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy end-blocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5 percent and not more than 99.0 percent of polydimethylsiloxane ([–(CH3)2SiO–]n),...
04. March 2016
Improving the solubility of BCS class 2 drugs is a continuing challenge for the pharmaceutical formulator. Improving solubility could allow for formulations using significantly less active and open the door to new dosage forms and avenues for lifecycle extensions. Creating solid dispersions are a promising way to improve drug solubility. Grace SilSol™6035 has a specifically engineered surface and pore distribution to enable stable amorphous dispersions by solvent deposition. Poorly soluble...
04. March 2016
The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid dispersions. Nifedipine (poorly water soluble drug), when prepared as solid dispersion showed increased solubility and dissolution rate. Solid dispersions of Nifedipine were prepared by using silsol 6035 as carrier in various proportions 10%, 20% and 30% by solvent loading (solvent droplet addition)method and various grades of silica by co-milling method in ratios of (1:1, 1:2 and 2:1). The...
11. January 2016
In the present study, we report the delivery of anti-cancer drug curcumin to cancer cells using mesoporous silica materials. A series of mesoporous silica material based drug delivery systems (S2, S4 and S6) were first designed and developed through the amine functionalization of KIT-6, MSU-2 and MCM-41 followed by the loading of curcumin. More
