28. May 2018
Orodispersible films (ODFs) are an advantageous dosage form to accomplish patient convenience and compliance in oral drug delivery. They provide a number of special application features, such as the ease of administration without water and suitability for patients with swallowing problems. However, this promising dosage form has been limited to immediate release formulations so far. The aim of this study was to develop a thin film produced by solvent casting, which is rapidly disintegrating...
27. September 2017
Many future drug products will be based on innovative manufacturing solutions, which will increase the need for a thorough understanding of the interplay between drug material properties and processability. In this study, hot melt extrusion of a drug-drug mixture with minimal amount of polymeric excipient was investigated.
01. September 2017
Abstract Hot-melt coating (HMC) as a solvent-free technology grants faster and more economic coating processes with reduced risk of dissolving the drug during the process. Moreover, traditional coating equipment can be modified to enable the HMC process. Despite the indubitable advantages and feasibility of the process, HMC is not well-known to pharmaceutical industry and its employment is still limited. The main aspect hindering the widespread application of this technique is the need of...
31. August 2017
This work aimed to obtain an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and dissolution rate by combining different polymers using hot melt extrusion (HME), according to a simplex centroid mixture design. For this, the polymers Plasdone® (PVP/VA), Klucel ELF® (HPC) and Soluplus® (SOL) were processed using a laboratory HME equipment operating without recirculation at constant temperature. Samples were characterized by physicochemical assays, as well as...
23. September 2015
With the Glatt MODCOS (Modular Continuous System) process insert, batch versions of the GPCG 2 and GPCG 10 series can be easily converted to continuous fluid bed systems and integrated into a continuous process chain. More Information & Video
24. June 2015
Determination of drug–polymer miscibility is critical for successful development of solid dispersions. This report details a practical method to predict miscibility and physical stability of drug with various polymers in solid dispersion and, especially, in melt extrudates by applying a film-casting technique. More
26. May 2015
Hot melt extrusion has been used in the plastic industry for almost 75 years. However, it is only in the past 10 to 15 years that it has gained wide acceptance in the pharmaceutical industry for the development of drug products and devices... http://www.stjohns.edu/academics/schools-and-colleges/college-pharmacy-and-health-sciences/symposiums-and-conferences/dr-charles-i-jarowski-industrial-pharmacy-symposium